Enhancing Skull Ultrasound Conductivity. Presentation at LiFT-2025

Expanding the Boundaries of Possibility: Research for Helping Patients with Tremor and Parkinson’s Disease

At the V.S. Buzaev International Medical Centre, we believe that non-invasive medicine should be accessible to everyone in need of assistance. That is why we are actively engaged in research and collaborate with leading scientific institutions to find new ways to treat complex diseases. A notable example of such collaboration is our joint work with Lomonosov Moscow State University.

What inspires us?

Tremor and Parkinson’s disease are conditions that can significantly impair patients’ quality of life. Modern technologies, such as MRI-guideded focused ultrasound treatment, open up new possibilities for helping such patients. However, until recently, this method was unavailable to many due to the low ultrasound conductivity of the skull bones. We set out to change this.

Research in the Service of Health

In collaboration with scientists from the Laboratory of Medical and Industrial Ultrasound at MSU, including PhD in Physics and Mathematics Alisa Alexandrovna Krohmal, we have developed a unique approach to preparing patients with a low skull permeability coefficient ( SDR). Our research has shown that medication therapy using alendronic acid can increase the bone density of the skull and make treatment with focused ultrasound accessible to a larger number of patients.

Results that Inspire

At the All-Russian Conference (Neurocampus) LiFT-2025 School of Young Scientists “Medical Neurotechnologies” Alisa Alexandrovna Krohmal presented the results of joint work. Clinical cases of patients who previously could not undergo successful treatment due to the characteristics of bone tissue were analyzed.

Here’s what we have achieved:

• Temperature Increase Impact: The average maximum temperature in the treatment area increased from 53.6 ° C up to 55.7 ° C. This improvement means that ultrasound has become more effective at penetrating through the skull bones.
• Growth of the coefficient SDR: After the course of therapy SDR increased from 0.378 to 0.424, which opened up the possibility for successful repeat procedures.
• Objective Changes in Bone Structure: Our method of analyzing CT images confirmed that alendronate contributes to the densification of trabecular bone, making it more conductive to ultrasound.

These results are not just numbers. They represent real changes that give patients, previously considered unsuitable for treatment, a chance to receive help. It’s an opportunity to regain control over their bodies, improve their quality of life, and engage in their favorite activities again.

We move forward together with research

Our collaboration with Lomonosov Moscow State University is an example of how research and medicine can unite for a single purpose: improving patients’ lives. We are proud that our center is becoming a platform for implementing advanced technologies that change people’s lives for the better.

We are ready to help you

If you or your loved ones suffer from tremor or Parkinson’s disease, know that we are working to make treatment accessible to everyone. Our research and advanced treatment methods help those who previously could not be helped. Contact us, and together we will find a solution!

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