Psychotic disorders, hallucinations in Parkinson’s disease

Elimination of Psychotic Disorders (Hallucinations and Psychosis) in Parkinson’s Disease

Atypical antipsychotics are the only medications for the treatment of psychotic disorders (hallucinations and psychosis) that are approved and available for use in the Russian Federation for patients with

This is Quetiapine (original Seroquel) and Clozapine.

Quetiapine minimally affects dopamine receptors, which means it is less likely to cause movement complications (and exacerbate parkinsonism)

In Parkinson’s disease, start with minimal doses before bedtime, with a possible gradual increase in dosage until achieving a clinical effect, OR until possible side effects occur.

Of the obvious side effects – sedation (drowsiness), falls, hypotensive effect (lowering blood pressure), prolongation of the interval QT, metabolic changes (hyperglycemia, dyslipidemia, weight gain)

Its use, like that of many “serious” medications, is associated with increased mortality in elderly patients with dementia

Therefore, in elderly people, the use of quetiapine (and other antipsychotics) should be strictly INDICATED (only for the correction of hallucinations and psychoses) and as short as possible in duration (ideally – no more than 3 months)

But in any case, the dosage and duration of the medication are determined INDIVIDUALLY and only by the attending physician.

Stay healthy!